Therapy-based approaches help reduce cannabis use short-term, but improvements often fade after nine months

A data synthesis found that CBT and motivational therapy improve short-term cannabis use outcomes, but effects typically fade by nine months, and no pharmacotherapy has been approved for cannabis use disorder.

Connor, Jason P et al.·European archives of psychiatry and clinical neuroscience·2025·Moderate EvidenceReview
RTHC-06248ReviewModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Review
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

Cognitive Behavioral Therapy (CBT) and Motivational Enhancement Therapy (MET) improved short-term cannabis use frequency and dependence severity, though abstinence outcomes were less consistent and improvements were not typically maintained at nine months. Treatments extending beyond four sessions were more effective. Adding Contingency Management improved outcomes. No pharmacotherapies have been approved for cannabis use disorder or withdrawal.

Key Numbers

CBT/MET treatments beyond 4 sessions were more effective than shorter programs. Benefits were typically not maintained at 9 months post-treatment. No pharmacotherapies are approved for cannabis use disorder.

How They Did This

Data synthesis integrating findings from high-level evidence studies on behavioral and pharmacological cannabis treatment approaches, prioritizing European data where available.

Why This Research Matters

Cannabis use disorder affects a growing number of people worldwide, yet treatment options remain limited. Understanding which approaches work, for how long, and what augments them helps clinicians set realistic expectations and plan treatment.

The Bigger Picture

The lack of approved medications for cannabis use disorder stands in contrast to treatment options available for alcohol and opioid use disorders. The finding that behavioral treatment gains fade highlights a need for maintenance or booster strategies.

What This Study Doesn't Tell Us

Relatively few European-specific studies were available. Synthesis approach is less rigorous than a formal systematic review or meta-analysis. Heterogeneity across included studies limits precision of conclusions.

Questions This Raises

  • ?Can booster sessions extend the durability of CBT/MET gains beyond nine months?
  • ?What pharmacological targets are most promising for cannabis use disorder?
  • ?Would digital interventions complement in-person therapy?

Trust & Context

Key Stat:
No approved medications for cannabis use disorder
Evidence Grade:
Integrative data synthesis drawing on high-level evidence, but limited European-specific data and less formal methodology than a systematic review.
Study Age:
2025 publication
Original Title:
Effectiveness of cannabis use and cannabis use disorder interventions: a European and international data synthesis.
Published In:
European archives of psychiatry and clinical neuroscience, 275(2), 327-339 (2025)
Database ID:
RTHC-06248

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

Summarizes existing research on a topic.

What do these levels mean? →

Frequently Asked Questions

What therapy works best for cannabis use disorder?

CBT and MET (or their combination) showed the most evidence for short-term improvement. Adding Contingency Management (reward-based incentives) improved outcomes further. Programs with more than four sessions outperformed shorter ones.

Are there medications for cannabis use disorder?

No pharmacotherapies have been approved for cannabis use disorder, cannabis withdrawal, or cannabis use management. Some medications are used off-label to manage withdrawal symptoms, but the evidence supporting them is weak.

Read More on RethinkTHC

Cite This Study

RTHC-06248·https://rethinkthc.com/research/RTHC-06248

APA

Connor, Jason P; Manthey, Jakob; Hall, Wayne; Stjepanović, Daniel. (2025). Effectiveness of cannabis use and cannabis use disorder interventions: a European and international data synthesis.. European archives of psychiatry and clinical neuroscience, 275(2), 327-339. https://doi.org/10.1007/s00406-024-01829-5

MLA

Connor, Jason P, et al. "Effectiveness of cannabis use and cannabis use disorder interventions: a European and international data synthesis.." European archives of psychiatry and clinical neuroscience, 2025. https://doi.org/10.1007/s00406-024-01829-5

RethinkTHC

RethinkTHC Research Database. "Effectiveness of cannabis use and cannabis use disorder inte..." RTHC-06248. Retrieved from https://rethinkthc.com/research/connor-2025-effectiveness-of-cannabis-use

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.