Teens Who Used Cannabis Reported Less Ability to Look Forward to Things

Among adolescents with mood and anxiety symptoms, those who used cannabis reported worse anticipatory anhedonia, the inability to look forward to pleasurable experiences, with more frequent use linked to worse symptoms.

Nguyen, Tram N B et al.·JAACAP open·2025·Preliminary EvidenceCross-Sectional
RTHC-07252Cross SectionalPreliminary Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Preliminary Evidence
Sample
N=153

What This Study Found

Adolescents who used cannabis endorsed worse anticipatory anhedonia (difficulty looking forward to pleasurable experiences) compared to those who never used or tried cannabis only once. More frequent cannabis use correlated with greater anticipatory anhedonia. Teens diagnosed with cannabis use disorder reported greater depression and anxiety than those with non-disordered use.

Key Numbers

153 adolescents; mean age 15.9 years; 64.1% female; 49 cannabis users identified; cannabis use disorder subgroup showed greater depression and anxiety than non-disordered users.

How They Did This

Cross-sectional study of 153 adolescents (mean age 15.9, 64.1% female) presenting with mood and anxiety symptoms. Cannabis use was quantified via clinician interviews, self-reports, and urine toxicology. Linear regression models assessed associations between cannabis use and anhedonia subconstructs, adjusting for age and sex.

Why This Research Matters

Anhedonia is a core symptom of depression and reflects dysfunction in the brain's reward system. Finding that cannabis use is specifically linked to anticipatory anhedonia in teens with mood symptoms suggests cannabis may compound reward-system problems in already vulnerable youth.

The Bigger Picture

This study connects two growing concerns: rising adolescent cannabis use and the neurobiological impact on developing reward systems. Anhedonia is particularly treatment-resistant and predicts poor outcomes in depression, making this association clinically meaningful.

What This Study Doesn't Tell Us

Small sample size (n=153) with cross-sectional design, which cannot determine whether cannabis causes anhedonia or anhedonic teens seek cannabis. Clinical sample may not generalize to community populations. Self-reported cannabis use may be underestimated.

Questions This Raises

  • ?Does cannabis use cause anticipatory anhedonia, or do teens with reward dysfunction gravitate toward cannabis?
  • ?Would anhedonia improve with cannabis cessation?
  • ?Are there sex differences in how cannabis affects reward processing in depressed adolescents?

Trust & Context

Key Stat:
More frequent cannabis use correlated with worse anticipatory anhedonia in teens with mood symptoms
Evidence Grade:
Preliminary: Small clinical sample (n=153) with cross-sectional design; important signal but requires larger longitudinal confirmation.
Study Age:
Published in 2025.
Original Title:
Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms.
Published In:
JAACAP open, 3(4), 1107-1117 (2025)
Database ID:
RTHC-07252

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

What is anticipatory anhedonia?

Anticipatory anhedonia is the inability to look forward to or feel excited about pleasurable experiences. It differs from consummatory anhedonia (inability to enjoy things in the moment) and is considered a core feature of depression linked to reward system dysfunction.

Why might cannabis affect the ability to feel pleasure?

Cannabis acts on the brain's endocannabinoid and dopamine systems, both of which are central to reward processing. During adolescence, these systems are still developing, and cannabis exposure may disrupt the normal maturation of reward circuits.

Read More on RethinkTHC

Cite This Study

RTHC-07252·https://rethinkthc.com/research/RTHC-07252

APA

Nguyen, Tram N B; Ely, Benjamin A; Vitale, Aria; Roske, Chloe; Richard, Jasmin T; Tobe, Russell H; Gabbay, Vilma. (2025). Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms.. JAACAP open, 3(4), 1107-1117. https://doi.org/10.1016/j.jaacop.2025.02.003

MLA

Nguyen, Tram N B, et al. "Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms.." JAACAP open, 2025. https://doi.org/10.1016/j.jaacop.2025.02.003

RethinkTHC

RethinkTHC Research Database. "Cannabis Use is Related to Anhedonia in Adolescents With Div..." RTHC-07252. Retrieved from https://rethinkthc.com/research/nguyen-2025-cannabis-use-is-related

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.