Hopelessness was the strongest unique predictor of cannabis use among young adolescents

Among 605 adolescents (mean age 13.2 years), cannabis users scored higher on nearly every mental health risk factor assessed, but hopelessness was the only variable uniquely associated with cannabis use after controlling for other factors.

Moreno-Mansilla, Sara et al.·Clinical child psychology and psychiatry·2021·Moderate EvidenceCross-Sectional
RTHC-03360Cross SectionalModerate Evidence2021RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Moderate Evidence
Sample
N=605

What This Study Found

Cannabis users scored significantly higher on anomalous reality perception (d = 0.60), hopelessness (d = 0.85), depression symptoms (d = 0.80), rumination (d = 0.48), and anxiety (d = 0.39). Suicide attempts were 3.4 times more common (25.9% vs 7.7%). Logistic regression showed hopelessness was the only unique predictor of cannabis use (OR 1.159, P = 0.033).

Key Numbers

605 adolescents; mean age 13.2; hopelessness d = 0.85; depression d = 0.80; anomalous perception d = 0.60; suicide attempts 25.9% users vs 7.7% non-users; hopelessness OR 1.159

How They Did This

Cross-sectional study of 605 adolescents in 7th-9th grades (mean age 13.2 years, 47% girls) assessed using validated questionnaires for anomalous perception, rumination, intolerance of uncertainty, hopelessness, depression, anxiety, and suicide attempts. Binary logistic regression identified unique predictors.

Why This Research Matters

Early adolescent cannabis use is increasing, and understanding which mental health factors are most tightly linked could inform targeted prevention. The finding that hopelessness specifically stands out is actionable for school-based mental health programs.

The Bigger Picture

Hopelessness is a modifiable risk factor. If it is both a driver of and consequence of early cannabis use, targeting hopelessness in prevention programs could potentially interrupt the cycle at a point where intervention is most practical.

What This Study Doesn't Tell Us

Cross-sectional design cannot determine whether hopelessness leads to cannabis use or vice versa. Spanish adolescent sample may not generalize globally. Self-report measures. Cannabis use was binary (yes/no) without frequency data.

Questions This Raises

  • ?Would hopelessness-targeted interventions reduce adolescent cannabis use?
  • ?Does cannabis use increase or decrease hopelessness over time?
  • ?Are these associations specific to early onset users or do they apply at all ages?

Trust & Context

Key Stat:
Hopelessness: the only unique predictor of cannabis use in early adolescents
Evidence Grade:
Solid sample size with validated measures, but cross-sectional design limits causal inference.
Study Age:
Published in 2021.
Original Title:
Cannabis use among early adolescents and transdiagnostic mental health risk factors.
Published In:
Clinical child psychology and psychiatry, 26(2), 531-543 (2021)
Database ID:
RTHC-03360

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

Are young teens who use cannabis more depressed?

Yes. Cannabis-using adolescents in this study scored significantly higher on depression (d = 0.80) and hopelessness (d = 0.85), with hopelessness being the only factor uniquely associated with cannabis use after controlling for other variables.

Were cannabis-using teens more likely to attempt suicide?

Yes. Among cannabis users, 25.9% reported a suicide attempt compared to 7.7% of non-users, though this cross-sectional association cannot determine causation.

Read More on RethinkTHC

Cite This Study

RTHC-03360·https://rethinkthc.com/research/RTHC-03360

APA

Moreno-Mansilla, Sara; Ricarte, Jorge J; Hallford, David J. (2021). Cannabis use among early adolescents and transdiagnostic mental health risk factors.. Clinical child psychology and psychiatry, 26(2), 531-543. https://doi.org/10.1177/1359104521994637

MLA

Moreno-Mansilla, Sara, et al. "Cannabis use among early adolescents and transdiagnostic mental health risk factors.." Clinical child psychology and psychiatry, 2021. https://doi.org/10.1177/1359104521994637

RethinkTHC

RethinkTHC Research Database. "Cannabis use among early adolescents and transdiagnostic men..." RTHC-03360. Retrieved from https://rethinkthc.com/research/moreno-mansilla-2021-cannabis-use-among-early

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.