Early and Frequent Teen Cannabis Use Linked to 51% More Mental Health and 86% More Physical Health Visits by Age 23

Teens who started cannabis before age 15 and used frequently had significantly higher rates of medical care for mental and physical health conditions in young adulthood, even after adjusting for 32 confounders measured from birth.

Martínez, Pablo et al.·JAMA network open·2025·Strong EvidenceLongitudinal Cohort
RTHC-07067Longitudinal CohortStrong Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Longitudinal Cohort
Evidence
Strong Evidence
Sample
N=1,591

What This Study Found

Three adolescent cannabis patterns were identified: nonuse (60%), late-onset after 15 (20%), and early/frequent before 15 (20%). Early/frequent users had 51% higher odds of mental health care (OR 1.51), 57% higher odds of common mental disorder care (OR 1.57), and 86% higher odds of physical health care (OR 1.86) compared to nonusers. Late-onset users showed increased physical but not mental health care utilization.

Key Numbers

N = 1,591 (51.4% female). 3 trajectory groups: nonuse 59.6%, late-onset 20.0%, early/frequent 20.4%. Early/frequent vs nonuse: mental disorder OR 1.51, common mental disorder OR 1.57, any physical condition OR 1.86, injuries OR 1.41, other physical diseases OR 1.47. Late-onset: physical condition OR 1.63 only.

How They Did This

Population-based birth cohort from the Quebec Longitudinal Study of Child Development linked to administrative medical databases. Self-reported cannabis use at ages 12, 13, 15, and 17. Medical care utilization tracked from ages 18-23. Analyses adjusted for 32 individual, family, and community-level confounders measured from birth to age 12 using overlap weights.

Why This Research Matters

This is among the strongest evidence linking adolescent cannabis patterns to concrete healthcare outcomes. By adjusting for 32 confounders measured before cannabis exposure began, it addresses the concern that pre-existing factors rather than cannabis itself drive the association.

The Bigger Picture

The distinction between early/frequent and late-onset patterns is critical for policy. Late-onset users (starting after 15) did not show excess mental health care utilization, suggesting that delaying initiation may be as important as preventing use entirely.

What This Study Doesn't Tell Us

Canadian birth cohort may not generalize to other populations. Medical care utilization reflects healthcare-seeking behavior, not just health status. Self-reported cannabis use may be underreported. Administrative data captures diagnoses given during visits but may miss undiagnosed conditions.

Questions This Raises

  • ?Would these patterns hold in jurisdictions with different healthcare access?
  • ?Does the increased physical health care utilization reflect injuries related to cannabis use or other factors?

Trust & Context

Key Stat:
86% higher odds of physical health care for early/frequent teen users
Evidence Grade:
Birth cohort linked to administrative data with 32 pre-exposure confounders. Among the strongest observational designs possible for this question. Published in JAMA Network Open.
Study Age:
Published in 2025 in JAMA Network Open with follow-up to age 23.
Original Title:
Health Service Use Among Young Adults With a History of Adolescent Cannabis Use.
Published In:
JAMA network open, 8(10), e2539977 (2025)
Database ID:
RTHC-07067

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Follows a group of people over time to track how outcomes develop.

What do these levels mean? →

Frequently Asked Questions

Does late-onset teen cannabis use also cause problems?

Late-onset users (starting after 15) had increased physical health care but no significant increase in mental health care compared to nonusers. This suggests that delaying initiation may protect against mental health consequences.

How do the researchers know it is cannabis and not other factors?

They adjusted for 32 confounders measured from birth to age 12, before cannabis use began. This includes family factors, mental health, socioeconomic status, and other early-life variables, making it unlikely that pre-existing differences fully explain the results.

Read More on RethinkTHC

Cite This Study

RTHC-07067·https://rethinkthc.com/research/RTHC-07067

APA

Martínez, Pablo; Chadi, Nicholas; Castellanos-Ryan, Natalie; Vergunst, Francis; Dorais, Marc; Séguin, Jean R; Vitaro, Frank; Temcheff, Caroline; Tremblay, Richard E; Boivin, Michel; Côté, Sylvana M; Geoffroy, Marie-Claude; Orri, Massimiliano. (2025). Health Service Use Among Young Adults With a History of Adolescent Cannabis Use.. JAMA network open, 8(10), e2539977. https://doi.org/10.1001/jamanetworkopen.2025.39977

MLA

Martínez, Pablo, et al. "Health Service Use Among Young Adults With a History of Adolescent Cannabis Use.." JAMA network open, 2025. https://doi.org/10.1001/jamanetworkopen.2025.39977

RethinkTHC

RethinkTHC Research Database. "Health Service Use Among Young Adults With a History of Adol..." RTHC-07067. Retrieved from https://rethinkthc.com/research/martinez-2025-health-service-use-among

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.