Can CBD protect newborn nerve cells after injury? ↗
Rat study finds CBD enhances motor neuron survival by 54% after neonatal nerve injury, with sustained benefits at 8 weeks through CB1 receptor-dependent mechanisms.
Research library — page 57
Browse more cannabis research, findings, methods, and limitations.
Should medicinal cannabis patients face zero-tolerance drug driving laws? ↗
Australian policy analysis finds zero-tolerance THC driving laws harm medicinal cannabis patients without evidence of greater road risk compared to other impairing prescription drugs.
Cannabis, Dopamine, and Addiction: How the Endocannabinoid System Modulates the Brain's Reward Circuit ↗
Cannabis activates the same dopamine reward pathway as all drugs of abuse. The endocannabinoid system's role in modulating these signals may offer new targets for treating addiction broadly.
Does medical marijuana improve quality of life for people using it for pain? ↗
Prospective study of 181 medical marijuana patients finds improved quality of life, pain, and anxiety over 6 weeks, but a decline in self-care measures.
Does daily cannabis use specifically affect impulsivity and ADHD symptoms in binge drinkers? ↗
Study of 730 binge-drinking young adults finds daily cannabis use linked to impulsive reward choice and hyperactive ADHD symptoms, with no effects from occasional use.
How does prenatal cannabinoid exposure affect the cerebellum of offspring? ↗
Rat study finds prenatal cannabinoid exposure paradoxically enhances mitochondrial function and promotes neuronal survival in offspring cerebellum, unlike harmful effects seen in other brain regions.
Can medical cannabis reduce autism-like behaviors in a genetic mouse model? ↗
Mouse autism model shows medical cannabis reduces repetitive behavior by 70% and anxiety, with THC appearing more important than CBD for core symptom improvement.
How does recent cannabis use affect symptoms in first-episode psychosis? ↗
Study of 247 first-episode psychosis patients finds cannabis users had less social withdrawal but more severe delusions, with no cognitive differences.
Does topical capsaicin cream work for cannabinoid hyperemesis syndrome? ↗
Meta-analysis of 7 studies (106 patients) finds topical capsaicin provides symptom relief for cannabinoid hyperemesis syndrome, with mean resolution time around 5.4 hours.
THC Stimulated Dental Pulp Cells to Form Bone-Like Tissue in a Lab — a Surprising Finding for Tooth Repair ↗
THC promoted mineralization and bone-like tissue formation in human dental pulp cells through CB1/CB2 receptors — an unexpected finding with potential for dental regeneration research.
Do genetic risk for schizophrenia and cannabis use independently affect psychosis symptoms? ↗
Large EU-GEI study finds genetic schizophrenia risk and daily cannabis use independently contribute to positive psychotic symptoms in both patients and healthy controls.
Does daily high-potency cannabis use lead to more psychotic symptoms? ↗
Large EU-GEI study finds daily high-potency cannabis use associated with the most severe positive psychotic symptoms in a dose-response pattern, while cannabis use was linked to fewer negative symptoms.
How effective is CBD-rich treatment for pain, anxiety, and depression in real patients? ↗
Real-world study of 279 patients finds CBD-rich treatment significantly improves pain, anxiety, and depression at 3 months, but only in those with moderate-to-severe symptoms.
What interventions actually work to prevent drugged driving? ↗
Systematic review of 28 studies finds packaging warnings, roadside testing, and motivational interviewing most effective for preventing drugged driving, while legal sanctions show little impact.
Is cannabis exposure associated with childhood leukemia rates across US states? ↗
Ecological analysis finds US states with higher cannabis use and legal cannabis have higher pediatric leukemia rates, though the study design cannot prove individual-level causation.
Do prenatal alcohol and cannabis have opposing effects on brain cells? ↗
Rat study finds prenatal alcohol and THC have opposing effects on hippocampal inhibitory neurons, with sex-specific effects and complex interactions when both are present.
What treatments work for cannabinoid hyperemesis syndrome in children and teens? ↗
Systematic review finds benzodiazepines, capsaicin, and haloperidol most effective for pediatric CHS, while traditional antiemetics frequently fail.
Can clinicians distinguish cannabis-induced psychosis from schizophrenia? ↗
Study of 307 inpatients finds cannabis-induced psychosis differs from schizophrenia with fewer negative symptoms and more mania, with cannabis use linked to nearly a decade earlier first hospitalization.
Does cannabis use worsen dissociation and functioning in first-episode psychosis over time? ↗
Prospective study finds cannabis-using psychosis patients have higher dissociation and worsening functioning over 8 months, while non-users improve.
Does cannabis use affect how long psychosis goes untreated? ↗
Study of 62 FEP patients finds cannabis use and treatment delay independently contribute to dissociative symptoms, though cannabis does not extend the untreated period itself.
How common is cannabis use among people with multiple sclerosis? ↗
Survey of 1,000 MS patients finds 30% currently use cannabis, with most using multiple routes and perceiving benefit, particularly among younger, lower-income, and more disabled patients.
Can EEG brain waves detect cannabis intoxication? ↗
Small crossover study finds specific EEG changes during cannabis intoxication, including decreased theta power and altered brain connectivity, suggesting potential for objective intoxication detection.
Does maternal cannabis use affect the placenta and child anxiety? ↗
PNAS study links maternal cannabis use to suppressed placental immune genes, elevated cortisol, and increased anxiety and hyperactivity in children aged 3-6.
Why are Florida patients using medical marijuana and is it working? ↗
Survey of 157 Florida medical marijuana patients finds anxiety and pain are top uses, with 65% reducing or stopping other medications.
Does cannabis use affect opioid addiction treatment outcomes? ↗
Study of 2,315 OUD patients finds overall cannabis use doesn't affect treatment outcomes, but daily cannabis use is associated with 39% lower odds of continued opioid use.
Do children in legal-cannabis states know more about marijuana? ↗
ABCD Study data from 11,875 children finds those in legal-cannabis states know more about marijuana but not other drugs, with no link between cannabis knowledge and behavioral problems.
How has cannabis use changed in Canada since legalization? ↗
Canadian national data shows cannabis use rose from 14% to 20% after legalization, with female rates matching male for the first time and legal purchasing increasing.
Is haloperidol better than ondansetron for treating cannabis hyperemesis syndrome? ↗
Triple-blind RCT finds haloperidol superior to ondansetron for CHS, with better symptom relief, fewer rescue medications, and 2.5-hour shorter ED stays.
How does vaped THC affect adolescent male and female rats differently? ↗
Animal study finds adolescent female rats metabolize vaped THC differently than males, with higher active metabolite levels and greater behavioral sensitivity at lower doses.
Are low-dose cannabis oils safe and effective for MS symptoms? ↗
Prospective study of 28 MS patients finds low-dose cannabis oils (4 mg THC, 7 mg CBD) significantly reduce pain, spasticity, and sleep problems without impairing function.
Does prenatal THC exposure create a dopamine system primed for psychosis? ↗
Rat study finds prenatal THC creates a latent dopamine dysfunction in offspring that emerges as psychotic-like behavior only when triggered by stress or drug challenge.
Does CBD counteract THC's psychotic-like effects when used together? ↗
Double-blind crossover study in 18 cannabis users finds CBD significantly reduces THC's psychotic-like effects when co-administered as a full-spectrum extract.
What Florida's Medical Marijuana Doctors Actually Do in Practice ↗
Survey of 116 Florida medical marijuana physicians found wide practice variation, with only half providing specific THC:CBD ratio recommendations and many relying on anecdotal information alongside research.
How Common Is Driving High in America? ↗
National survey of 128,205 adults found 4.5% drove under the influence of cannabis, with rates climbing sharply among daily users (57% predicted probability) and those with cannabis use disorder (63.8%).
Mixed Tobacco and Marijuana Smoking Linked to Rare Lung Condition ↗
A 48-year-old man with long-term tobacco and cannabis smoking developed vanishing lung syndrome, a rare form of severe emphysema, highlighting potential additive respiratory risks from dual use.
One in Five People with MS Uses Cannabis for Symptom Relief ↗
Survey of 3,249 MS patients found 20% currently use cannabis for symptoms like spasticity (80%), pain (69%), and sleep (61%), while many non-users cited insufficient data on safety and efficacy.
Low-Dose THC Reduced Anxiety in Female Rats but Not Males — and CBD Blocked the Anxious Response at Higher Doses ↗
Female rats showed biphasic THC anxiety responses that males didn't — anxiolytic at low doses, anxiogenic at high. CBD blocked the anxiety and enhanced the calm.
People with Psychosis Report More Intense Reactions to Cannabis ↗
Multi-national study found first-episode psychosis patients reported more psychotic-like experiences during cannabis intoxication than controls, with sensitivity increasing at higher use levels, while euphoric experiences did not differ.
Psychosis Without Cannabis History Shows Worse Eye Movement Control ↗
Study of 91 participants found that psychosis patients without cannabis history had worse smooth pursuit eye movements than those with cannabis history, suggesting less severe neurobiological impairment in cannabis-associated psychosis.
Cannabinoid Hyperemesis Syndrome Drives Higher Healthcare Costs ↗
Study found patients with cannabinoid hyperemesis syndrome consumed more healthcare resources than non-users, driven by repeated evaluations before correct diagnosis, though cost differences were not consistently statistically significant.
One-Third of NYC Families in Apartments Report Marijuana Smoke Drifting In ↗
Survey of 382 NYC families found 31% reported marijuana smoke entering their homes while with their children, with public housing residents 3.45 times more likely to be exposed.
One in Five Toddlers Tested Positive for Marijuana Metabolites ↗
Study of 53 young children in NYC found 20.8% had detectable marijuana metabolites in their urine, with rates nearly tripling in housing where smoking was allowed.
Cannabis Affects Male and Female Brains Differently on Cognitive Tests ↗
Study of 171 young regular cannabis users found sex-specific cognitive effects: males had poorer visual memory while females showed worse attention and executive function, with effect sizes in the medium-to-large range.
Twin Study Suggests Cannabis-Psychosis Link May Be Due to Shared Genetics ↗
Study of 1,544 twins found that while cannabis use was associated with higher psychoticism scores, within-twin-pair comparisons showed no causal effect, suggesting shared genetics explain the link.
Cannabis Users with Schizophrenia Respond Similarly to Treatment but Relapse More ↗
Study of 98 first-episode schizophrenia patients found cannabis users responded similarly to antipsychotic treatment over 24 months, but more frequent use predicted higher relapse risk.
Medical Cannabis Users Report Better Quality of Life Than Non-Users ↗
Study of 1,276 participants found medical cannabis users reported better quality of life, less pain and anxiety, and fewer ER visits, with longitudinal data suggesting cannabis use may contribute to the differences.
Quitting Cannabis Reverses DNA Changes in Sperm ↗
Study found that cannabis-related DNA methylation changes in sperm, concentrated at developmental genes, were significantly diminished after 77 days of abstinence, suggesting reversibility.
Cannabis-Based Spray Reduced Tourette Tics by Over 90% ↗
A 25-year-old with Tourette syndrome saw over 90% tic reduction using nabiximols spray as needed, after standard medication failed.
What Makes People Think It's OK to Drive High? ↗
Survey of 2,084 adults found that driving-while-high behavior is driven by a system of beliefs including attitudes, social norms, and perceived control, with intention being a stronger predictor than willingness alone.
How Cannabis Cues Light Up the Brain in Regular Users ↗
Systematic review of 18 fMRI studies found regular cannabis users show consistently heightened brain activity in reward, executive control, and memory regions when exposed to cannabis cues, with preliminary links to craving.