Research library — page 134

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2016 / Review / Not Graded evidence

THC and dopamine: acute effects differ from long-term associations ↗

THC and dopamine: acute effects differ from long-term associations

2017 / Observational / Not Graded evidence

Online CBD labels often differed from laboratory measurements ↗

Online CBD labels often differed from laboratory measurements

2017 / Review / Not Graded evidence

Lower-risk cannabis guidelines address modifiable patterns of use ↗

Lower-risk cannabis guidelines address modifiable patterns of use

1990 / Experimental / Not Graded evidence

A small 1990 study found little evidence of a next-morning cannabis hangover ↗

A small 1990 study found little evidence of a next-morning cannabis hangover

2018 / Systematic Review / Not Graded evidence

A review identified cannabis contaminants and major gaps in human-risk data ↗

A review identified cannabis contaminants and major gaps in human-risk data

2020 / Experimental / Not Graded evidence

CBD with THC produced positive urine confirmations in a small controlled study ↗

CBD with THC produced positive urine confirmations in a small controlled study

2012 / Case Control / Not Graded evidence

An AKT1 variant modified a cannabis–psychosis association in one case-control study ↗

An AKT1 variant modified a cannabis–psychosis association in one case-control study

1996 / Laboratory Study / Not Graded evidence

Researchers characterized FAAH, an enzyme that breaks down fatty-acid amides ↗

Researchers characterized FAAH, an enzyme that breaks down fatty-acid amides

1986 / Laboratory Study / Not Graded evidence

A 1986 experiment linked cannabinoid responses to Gi signaling ↗

A 1986 experiment linked cannabinoid responses to Gi signaling

Withdrawal
Addiction
Anxiety
Depression
Sleep
Cognition
Psychosis
Pain
Neuroscience
Dopamine
Youth
Pregnancy
Cardiovascular
Respiratory
Harm Reduction
Medical Cannabis
Cbd
Ptsd
Tolerance
Potency
Sex Differences
Appetite
Epilepsy
Exercise
Drug Interactions
Driving
Mental Health
Quitting
Genetics
Legalization
Workplace
Seniors
Cancer
Inflammation
Synthetic Cannabinoids
Microdosing

Irritability
Insomnia (Withdrawal)
Appetite Loss (Withdrawal)
Nausea (Withdrawal)
Withdrawal Timeline
Withdrawal Severity
Withdrawal Prevalence
Cannabis Withdrawal Scale (CWS)
Withdrawal Checklist (WC)
Restlessness
Anger / Aggression
Depressed Mood (Withdrawal)
Anxiety (Withdrawal)
Shakiness / Tremor
Craving
DSM-5 Cannabis Withdrawal Criteria
Withdrawal in Heavy Users
Withdrawal Duration
Fatigue (Withdrawal)
Emotional Lability / Mood Swings
Nervousness / Anxiousness
Weight Loss (Withdrawal)
Sleep-Onset Insomnia (Withdrawal)
Mood Swings (Withdrawal)
Stomach Cramps (Withdrawal)
Cannabis Use Disorder (CUD)
CUD Prevalence
CUD DSM-5 Criteria
Dependence Rates
Compulsive Use
Loss of Control
Escalation of Use
CUDIT-R Screening Tool
Severity of Dependence Scale (SDS)
Problematic Use
Cross-Addiction / Polysubstance
Gateway Hypothesis
Relapse
Cue Reactivity
Negative Reinforcement
Reward Deficiency
Age of Onset
Daily / Near-Daily Use
Lifetime Risk of Dependence
Self-Medication
Social Consequences of Use
CUD Treatment Gap
Failed Quit Attempts
Craving / Urges
Irritability (Addiction)
Anxiety (Addiction)
Mood Swings (Addiction)
Cognitive Impairment (Addiction)
Amotivation (Addiction)
Sleep Disruption (Addiction)
Social Isolation (Addiction)
Neglect of Responsibilities
Continued Use Despite Harm
Generalized Anxiety Disorder (GAD)
Social Anxiety Disorder
Panic Attacks
Panic Disorder
Agoraphobia
Anxiolytic Effects
Anxiogenic Effects
Dose-Response (Anxiety)
Biphasic Effect on Anxiety
CBD for Anxiety
THC-Induced Anxiety
Performance Anxiety
Obsessive-Compulsive Disorder (OCD)
Specific Phobias
State-Trait Anxiety Inventory (STAI)
Anxiety Sensitivity
Health Anxiety
Separation Anxiety
Test / Exam Anxiety
Cannabis-Induced Panic Attack
Anticipatory Anxiety
Social Anxiety Symptoms
Depersonalization (Anxiety)
Intrusive Thoughts
Rumination (Anxiety)
Muscle Tension (Anxiety)
Jaw Clenching (Anxiety)
Trembling / Shaking
Nervous Stomach
Heart Palpitations (Anxiety)
Restlessness (Anxiety)
Irritability (Anxiety)
Insomnia (Anxiety)
Dry Mouth (Anxiety)
Sweating (Anxiety)
Nausea (Anxiety)
Dizziness (Anxiety)
Sensory Overload (Anxiety)
Existential Dread
Major Depressive Disorder (MDD)
Depressive Symptoms
Anhedonia
Suicidal Ideation
Suicide Risk
Self-Harm
Bipolar Disorder
PHQ-9 Depression Scale
Treatment-Resistant Depression
Neuroinflammation & Depression
Mood Regulation
Insomnia
Sleep Onset Latency
REM Sleep
REM Suppression
Slow-Wave Sleep (Deep Sleep)
Sleep Architecture
Sleep Quality
Sleep Duration
Sleep Efficiency
Sleep Apnea
Nightmares
Circadian Rhythm
Polysomnography (PSG)
CBN for Sleep
THC for Sleep
Daytime Sleepiness
Sleep Hygiene
Restless Legs Syndrome
Next-Day Impairment
Narcolepsy
Fragmented Sleep
Excessive Daytime Sleepiness
Sleep Latency
NREM Sleep
Short-Term Memory
Working Memory
Long-Term Memory
Verbal Memory
Episodic Memory
Attention
Executive Function
Decision-Making
Processing Speed
IQ / Intelligence
Reaction Time
Cognitive Recovery After Abstinence
Acute Intoxication Effects
Residual Cognitive Effects
Neuropsychological Testing
Inhibitory Control
Cognitive Flexibility
Hippocampus
Prefrontal Cortex
Brain Fog
Learning
Academic Performance
Creativity
Motivation & Cognitive Effort
Spatial Memory / Navigation
Risk Assessment / Risky Decision-Making
Poor Concentration
Decision-Making Difficulty
Confusion
Mental Fatigue
Clouded Thinking
Memory Performance
Cognitive Dysfunction
Memory
Language Skills
Schizophrenia
Schizophrenia Risk
Psychotic Disorders
First-Episode Psychosis
Cannabis-Induced Psychosis
Psychotic Symptoms
Hallucinations
Delusions
Thought Disorder
Dose-Response Relationship
High-Potency Cannabis & Psychosis
Age of Onset & Psychosis Risk
Genetic Vulnerability (AKT1, COMT)
Antipsychotic Interaction
CBD as Antipsychotic
Psychosis Prevalence
Prodromal / At-Risk Mental State
Derealization / Depersonalization
Negative Symptoms (Schizophrenia)
Cognitive Symptoms in Psychosis
Visual Hallucinations
Auditory Hallucinations
Disorganized Thinking
Catatonia
Persecutory Beliefs
Ideas of Reference
Social Withdrawal (Psychosis)
Neuroinflammatory Diseases
Chronic Pain
Neuropathic Pain
Nociceptive Pain
Arthritis Pain
Cancer Pain
Postoperative Pain
Opioid-Sparing Effect
Opioid Substitution
Analgesic Effects
Hyperalgesia
Pain Catastrophizing
Visual Analog Scale (VAS)
Endometriosis Pain
Menstrual Pain / Dysmenorrhea
Multiple Sclerosis Pain
Spasticity
Knee Pain / Osteoarthritis
Pelvic Pain / Vulvodynia
Dental Pain
Sickle Cell Pain
Endocannabinoid System (ECS)
CB1 Receptor
CB2 Receptor
Anandamide (AEA)
2-AG (2-Arachidonoylglycerol)
FAAH Enzyme
MAGL Enzyme
Endocannabinoid Tone
Retrograde Signaling
Synaptic Plasticity
Long-Term Potentiation (LTP)
Long-Term Depression (LTD)
Neurogenesis
Neuroimaging (fMRI, PET)
White Matter Integrity
Gray Matter Volume
Brain Connectivity
Default Mode Network
Neurotransmitter Release
GPR55 Receptor
TRPV1 Receptor
Blood-Brain Barrier
Neuroprotection
Excitotoxicity
GABAergic Neurons
Amygdala
Cerebellum
Basal Ganglia
Anterior Cingulate Cortex
Clinical Endocannabinoid Deficiency (CED)
EEG / Electrophysiology
Endocannabinoid Deficiency Theory
Dizziness
Numbness
Tremor
Seizures
Balance Problems
Coordination Problems / Ataxia
Dysarthria (Slurred Speech)
Sensory Overload
Neural Hypersensitivity
Reward System
Mesolimbic Pathway
Mesocortical Pathway
Ventral Tegmental Area (VTA)
Nucleus Accumbens
Striatum
Dopamine Release
Dopamine Blunting
Motivation
Dopamine Synthesis Capacity
Reward Anticipation
Reward Learning
Effort-Based Decision Making
PET Imaging (Dopamine)
Dopamine Recovery After Abstinence
Chronic THC & Dopamine
Acute THC & Dopamine
Nigrostriatal Pathway
Apathy
Amotivation / Lack of Drive
Reward Insensitivity
Adolescent Brain Development
Teen Use Prevalence
Early-Onset Use (<15 years)
Developmental Neurotoxicity
Prefrontal Cortex Maturation
School Performance
College Students
High School Use
Prevention Programs
Perception of Risk
Young Adult Use (18-25)
Vaping / E-Cigarette Cannabis Use
Social Media Influence
Parental Cannabis Use
Prenatal Exposure & Youth Outcomes
Transition-Age Youth (16-24)
Youth Mental Health & Cannabis
Youth Psychosis Risk
Youth Emergency Department Visits
Family History of Use
Anxiety (Youth)
Depression (Youth)
Psychosis (Youth)
Cognitive Impairment (Youth)
Memory Problems (Youth)
Attention Problems (Youth)
Motivation Problems (Youth)
Mood Instability (Youth)
Sleep Problems (Youth)
Social Withdrawal (Youth)
Paranoia (Youth)
Suicidal Ideation (Youth)
Prenatal Cannabis Exposure
Fetal Development
Low Birth Weight
Preterm Birth
Placental Effects
Breastfeeding / Lactation
THC in Breast Milk
Neonatal Outcomes
NICU Admission
Prenatal Use Prevalence
Child Neurodevelopmental Outcomes
Male Fertility / Sperm Quality
Female Fertility / Ovulation
ECS in Pregnancy
Anxiety (Pregnancy)
Depression (Pregnancy)
Heart Rate / Tachycardia
Blood Pressure
Hypertension
Myocardial Infarction (Heart Attack)
Stroke
Arrhythmia
Cardiac Output
Cardiovascular Mortality
Coronary Artery Disease
Heart Failure
Peripheral Vascular Disease
Young Adults & Cardiac Risk
Cannabis-Associated Chest Pain
Tachycardia
Heart Palpitations
Chest Pain
Cardiac Arrest
Chronic Bronchitis
Chronic Cough
Sputum Production
Wheezing
Lung Function (FEV1, FVC)
COPD
Lung Cancer
Airway Inflammation
Smoking vs Vaping
Vaping Lung Injury (EVALI)
Bronchodilation
Asthma
Spirometry
Dry Herb Vaporizer
Pulmonary Function Testing
Dabbing / Concentrate Inhalation Risks
Cannabis Smoke Composition
Shortness of Breath / Dyspnea
Lung Irritation
Decreased Lung Capacity
Respiratory Failure
Lower-Risk Cannabis Use Guidelines (LRCUG)
Dosing Guidelines
Route of Administration
Edibles Safety
Safer Use Practices
Frequency Reduction
Non-Smoking Methods
THC:CBD Ratio
Product Labeling Accuracy
Contaminants (Pesticides, Heavy Metals, Mold)
Lab Testing
Emergency Department Visits
Accidental Ingestion (Children)
Cannabis Poisoning
Combination with Alcohol/Drugs
Tolerance & Harm Reduction
Cannabis Use Tracking / Journaling
Drug Checking / Potency Testing
Harm Reduction for Youth
Safer Supply / Regulated Access
Tachycardia Management
Panic Attack Management
Nausea Management
Anxiety Symptom Management
Cottonmouth / Dry Mouth Management
Dizziness Management
Clinical Trials
Randomized Controlled Trials (RCTs)
Systematic Reviews / Meta-Analyses
Medical Cannabis Access / Programs
Patient-Reported Outcomes
Dronabinol (Marinol)
Nabilone (Cesamet)
Nabiximols (Sativex)
Epidiolex
Whole-Plant Medicine
Entourage Effect
Qualifying Conditions
Placebo-Controlled Studies
Therapeutic Index
Adverse Events in Clinical Settings
Medical vs Recreational Use
Compassionate Use / Expanded Access
Cannabis Pharmacy / Dispensary
Patient Education
Telehealth Cannabis Consultations
Real-World Evidence (RWE)
Observational Studies
Cannabis Patient Registries
Myrcene
Beta-Caryophyllene
CBG (Cannabigerol)
CBN (Cannabinol)
CBC (Cannabichromene)
THCA (Tetrahydrocannabinolic Acid)
CBDV (Cannabidivarin)
Chemovars / Chemical Profiles
Cannabidiol
Full-Spectrum CBD
CBD Bioavailability
CBD Pharmacokinetics
CBD for Anxiety
CBD for Pain
CBD for Sleep
CBD for Epilepsy
CBD Anti-Inflammatory
CBD Antipsychotic Properties
CBD Neuroprotective
CBD Safety Profile
CBD Drug Interactions
CBD Hepatotoxicity / Liver
CBD Dose-Response
Hemp-Derived CBD
CBD for Addiction Treatment
CBD & 5-HT1A Receptor
CBD Product Quality / Mislabeling
CBD for Skin Conditions
CBD for IBS / Gut Health
CBD for PTSD
CBD for Autism
CBD for Diabetes
CBD for Nausea
CBD vs THC Comparison
CBD for Pets / Veterinary
Trauma
PTSD Nightmares
Hyperarousal
Avoidance Symptoms
Emotional Numbing
Veteran Studies
Military PTSD
Sexual Trauma
Childhood Trauma / ACEs
Nabilone for PTSD
PCL-5 (PTSD Checklist)
CAPS-5 (Clinician-Administered PTSD Scale)
Endocannabinoid Deficiency & PTSD
PTSD Sleep Disturbance
PTSD & Substance Use Comorbidity
Complex PTSD (C-PTSD)
Dissociation (PTSD)
Guilt / Shame (PTSD)
Suicidal Ideation (PTSD)
CB1 Receptor Downregulation
Receptor Upregulation (Recovery)
Receptor Desensitization
Receptor Internalization
Tolerance Development Timeline
Tolerance Reversal
Cross-Tolerance
Functional Tolerance
Tolerance to Impairment
Tolerance to Therapeutic Effects
PET CB1 Receptor Availability
Heavy Use & Tolerance
Dose Escalation
48-Hour CB1 Reset
Individual Variation in Tolerance
THC Concentration Trends
High-Potency Cannabis
Concentrates (Dabs, Wax, Shatter)
Flower Potency
Edible Potency
Vape Cartridge Potency
Hash / Hashish
Potency & Psychosis Risk
Potency & Dependence Risk
Potency Labeling Accuracy
THC Trends Over Time
Total THC Metric
CBD:THC Ratio
Dose Equivalence Across Products
Standard THC Unit
Potency Caps / Regulation
Male vs Female Responses
Estrogen & Cannabinoids
Progesterone & Cannabinoids
Testosterone & Cannabinoids
Faster Tolerance in Females
Female-Specific Withdrawal
Sex Differences in Dependence
Sex Differences in Pain Response
Sex Differences in Anxiety Response
Sex Differences in Cognitive Effects
Sex Differences in Metabolism
Gender Differences in Use Patterns
Hormonal Disruption
Appetite Stimulation
Appetite Suppression (THCV)
Nausea
Antiemetic Effects
Vomiting
Cannabinoid Hyperemesis Syndrome
CHS
Weight Gain
Weight Loss
Obesity
Cachexia / Wasting Syndrome
HIV/AIDS Wasting
Chemotherapy-Induced Nausea
Eating Disorders
Anorexia
THCV (Appetite Suppressant)
Cottonmouth / Dry Mouth
Dry Mouth
Loss of Appetite
Increased Appetite / Hyperphagia
Stomach Cramps
Seizures
Epilepsy (General)
Dravet Syndrome
Lennox-Gastaut Syndrome
Tuberous Sclerosis Complex
Epidiolex Clinical Trials
Treatment-Resistant Epilepsy
Seizure Frequency Reduction
Anticonvulsant Properties
Anti-Epileptic Drug Interaction
Clobazam-CBD Interaction
Valproate-CBD Interaction
Pediatric Epilepsy
EEG Findings
Absence Seizures
West Syndrome / Infantile Spasms
Myoclonic Seizure
Runner's High
Endocannabinoids During Exercise
Anandamide & Exercise
Exercise Recovery
Anti-Inflammatory & Recovery
Exercise Motivation
Exercise Enjoyment
Athletic Performance
CBD for Exercise Recovery
Endurance Sports
Running
Inflammation (Exercise)
Alcohol Interaction
Opioid Interaction
Benzodiazepine Interaction
SSRI Interaction
Antidepressant Interaction
Cocaine Interaction
Warfarin Interaction
Statin Interaction
CYP3A4 Inhibition
CYP2C9 Inhibition
CYP2C19 Inhibition
Polypharmacy
Sedative / CNS Depressant Interaction
Blood Thinner Interaction
Anticonvulsant Interaction
Metformin Interaction
Insulin Interaction
CYP2D6 Inhibition
CYP1A2 Inhibition
Impaired Driving
DUI / DUID
Accident Risk
Fatal Crash Risk
Reaction Time
Lane Tracking / Weaving
Divided Attention
Driving Simulator Studies
THC Blood Levels & Impairment
Per Se THC Limits
Drug Recognition Expert (DRE)
Combined Alcohol + Cannabis Driving
Tolerance & Driving Ability
Next-Day / Residual Impairment
Crash Culpability Studies
Legalization & Crash Rates
Drowsiness (Driving)
Psychiatric Comorbidity
Dual Diagnosis
Self-Medication Hypothesis
Stress
Emotional Regulation
Dissociation
Personality Disorders
Psychotic Disorders
ADHD
Autism Spectrum Disorder
Eating Disorders
Quality of Life
Subjective Well-Being
Coping Motives
Psychotropic Medication Use
Trauma-Informed Care
Substance Use Disorder (General)
Emotional Dysregulation
Social Skills / Social Functioning
Mood Swings
Irritability
Amotivation
Emotional Blunting
Increased Anxiety
Panic Attacks
Hopelessness
Suicidal Ideation
Social Withdrawal
Fatigue / Low Energy
Insomnia
Hypersomnia
Psychomotor Retardation
Concentration Difficulty
Derealization
Depersonalization
Cognitive Dysfunction
Cognitive Impairment
Anxiety (Mental Health)
Internalizing Problems
Externalizing Problems
Family Conflict
Sleep Problems
Cessation Strategies
Cognitive Behavioral Therapy (CBT)
Motivational Enhancement Therapy (MET)
Contingency Management
Motivational Interviewing (MI)
Twelve-Step / MA / NA
Quit Apps / Digital Interventions
Pharmacotherapy for CUD
Quit Rates / Success Rates
Relapse Prevention
Readiness to Change
Treatment Seeking
Self-Guided Quitting
Irritability (Quitting)
Insomnia (Quitting)
Night Sweats (Quitting)
Anxiety (Quitting)
Depression (Quitting)
Appetite Loss (Quitting)
Nausea (Quitting)
Headaches (Quitting)
Fatigue (Quitting)
Mood Swings (Quitting)
Craving / Urges (Quitting)
Restlessness (Quitting)
Sweating (Quitting)
Concentration Difficulty (Quitting)
Emotional Lability (Quitting)
CYP2C9 Enzyme
CYP2C19 Enzyme
CYP3A4 Enzyme
Pharmacogenomics
THC Metabolism Genetics
Genetic Predisposition to CUD
Heritability of Cannabis Use
Genome-Wide Association Studies (GWAS)
CNR1 Gene (CB1 Receptor)
CNR2 Gene (CB2 Receptor)
FAAH Gene Variants
Polygenic Risk Score
Gene-Environment Interaction
Use Rates Post-Legalization
Public Health Outcomes
ED Visits Post-Legalization
Tax Revenue
Black Market / Illicit Market
Social Equity / Racial Justice
Decriminalization
Medical vs Recreational Policy
Cannabis Regulation Models
Alcohol Substitution Effect
Potency Limits Policy
Advertising Restrictions
Packaging / Child-Resistant Safety
Criminalization & Health Effects
State vs Federal Law Conflict
Expungement / Record Clearing
Employment Impacts Post-Legalization
Drug Testing
Urine Drug Testing
Oral Fluid Testing
THC Detection Window
Impairment at Work
Workplace Accidents
Job Performance
Absenteeism
Safety-Sensitive Positions
Employment Discrimination
Workplace Cannabis Policy
Reasonable Accommodation
THC-COOH (Metabolite Detection)
Drug Test Cutoff Levels
Pre-Employment Testing Trends
Elderly Use Prevalence
Geriatric Pharmacology
Falls Risk
Polypharmacy in Seniors
Medication Interactions (Seniors)
Cognitive Decline
Dementia
Alzheimer's Disease
Parkinson's Disease
Chronic Pain (Seniors)
Sleep Disorders (Seniors)
Palliative Care
Late-Onset Cannabis Use
Caregiver Perspectives
Nursing Home / Long-Term Care
Dizziness / Orthostasis
Decreased Hepatic Clearance
Pain Management Approaches (Seniors)
Agitation in Dementia
Confusion (Seniors)
Drowsiness / Sedation (Seniors)
Anxiety (Seniors)
Palliative Care (Cancer)
Cancer Pain Management
Appetite Stimulation (Cancer)
Cancer Cachexia
Apoptosis
Anti-Proliferative Effects
Angiogenesis Inhibition
Glioblastoma / Brain Cancer
Breast Cancer
Colorectal Cancer
Lung Cancer (Treatment)
Quality of Life (Cancer)
Cancer Survival
In Vitro Tumor Studies
Liver Cancer (Hepatocellular)
Cancer Immunotherapy & Cannabis
Cancer-Related Anxiety & Distress
Cancer Pain Symptoms
Cancer-Related Fatigue
Cancer-Related Depression
Cancer-Related Nausea
Cancer-Related Vomiting
Cancer-Related Appetite Loss
Anti-Inflammatory Properties
Pro-Inflammatory Effects
Cytokines
TNF-alpha
Interleukins (IL-6, IL-1beta, IL-10)
NF-kappa-B Pathway
Oxidative Stress
Autoimmune Disease
Rheumatoid Arthritis
Osteoarthritis
Inflammatory Bowel Disease (IBD)
Multiple Sclerosis
Neuroinflammation
Microglia
Immune Modulation
Immune Suppression
T-Cell Function
Psoriasis
Chronic Low-Grade Inflammation
C-Reactive Protein (CRP)
Gut Microbiome
Type 1 Diabetes (Autoimmune)
COX-2 Inhibition
HHC (Hexahydrocannabinol)
Novel / Semi-Synthetic Cannabinoids
Synthetic Cannabinoid Toxicity
Overdose / Poisoning
Psychosis (Synthetic Cannabinoids)
Hemp-Derived Compounds
Chemical Conversion Process
Unregulated Market
Detection / Testing Challenges
Emergency Department Visits
Tachycardia (Synthetic)
Vomiting (Synthetic)
Confusion (Synthetic)
Numbness (Synthetic)
Nausea (Synthetic)