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Study breakdown

Researchers characterized FAAH, an enzyme that breaks down fatty-acid amides

Laboratory StudyNot Graded evidence

What the experiment established

Cravatt and colleagues isolated, cloned and expressed an enzyme from rat liver membranes. It broke down oleamide and also anandamide, supporting the name fatty-acid amide hydrolase, or FAAH. This supplied a molecular tool for studying how those signaling compounds are inactivated. Original paper.

What it did not test

This was biochemical research, not a trial of a treatment in people. Identifying an enzyme and its substrates does not establish the clinical benefit or safety of inhibiting it. The finding is a step in understanding endocannabinoid signaling; conclusions about a particular drug require separate evidence.

Read the original research

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides.

Nature

Citation

B F Cravatt; D K Giang; S P Mayfield; D L Boger; R A Lerner; N B Gilula. (1996). Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides.. Nature. https://doi.org/10.1038/384083a0