Five Years After Canadian Legalization, Cannabis Use Rose Modestly but Misuse Actually Decreased

In a 5-year prospective study of 1,428 Canadian adults, cannabis use frequency increased modestly (1.75% more days over 5 years) while cannabis misuse scores decreased, with frequent pre-legalization users showing the largest reductions in both use and misuse.

McDonald, André J et al.·JAMA network open·2025·Strong EvidenceProspective Cohort
RTHC-07099Prospective CohortStrong Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Prospective Cohort
Evidence
Strong Evidence
Sample
N=1,428

What This Study Found

Cannabis use frequency increased by 0.35% of days per year overall (1.75% over 5 years). CUDIT-R misuse scores decreased by 0.08 points per year (0.4 over 5 years). Critically, pre-legalization frequent consumers showed the largest decreases in both use and misuse, while occasional users and nonusers showed modest increases. Product preferences shifted from dried flower toward edibles, liquids, and vape pens.

Key Numbers

N = 1,428. 60.2% female. Mean age 34.5. 11 waves, 90% retention. Use: +0.35% of days/year. CUDIT-R: -0.08/year (scale 0-32). Frequent pre-legalization users: largest decreases. Nonusers: modest increases. Product shift: away from flower toward edibles and vape.

How They Did This

Prospective cohort study with up to 11 biannual assessments from September 2018 to October 2023 in Ontario, Canada. 1,428 community-dwelling adults aged 18-65. Mean 90% retention across all waves. Linear mixed-effects modeling assessed changes in cannabis use frequency and CUDIT-R scores.

Why This Research Matters

This is among the first longitudinal studies to track the same individuals through cannabis legalization. The finding that misuse decreased even as use increased, and that frequent users improved the most, provides the most nuanced picture yet of legalization's within-person effects.

The Bigger Picture

The decrease in misuse among frequent users may reflect the normalization and regulation of cannabis removing some of the risk-taking behavior associated with illegal use. The product diversification (from flower to edibles) aligns with a market maturation that could have both positive (less smoking) and negative (delayed onset risks) public health implications.

What This Study Doesn't Tell Us

Ontario-specific population. Self-reported use and misuse. The COVID-19 pandemic overlapped with the study period, confounding interpretation. Attrition could bias results if those worsening dropped out.

Questions This Raises

  • ?Will the misuse decrease continue beyond 5 years?
  • ?Is the product shift toward edibles a net positive or negative for public health?

Trust & Context

Key Stat:
Misuse decreased even as use frequency increased over 5 years
Evidence Grade:
Prospective cohort with 90% retention over 5 years and 11 waves. Among the strongest longitudinal evidence on legalization effects. Published in JAMA Network Open.
Study Age:
Published in 2025 in JAMA Network Open with data through 2023.
Original Title:
Cannabis Use and Misuse Following Recreational Cannabis Legalization.
Published In:
JAMA network open, 8(4), e256551 (2025)
Database ID:
RTHC-07099

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Enrolls participants and follows them forward in time.

What do these levels mean? →

Frequently Asked Questions

Did legalization make cannabis use worse?

Use frequency increased modestly, but misuse scores actually decreased. The people who used most heavily before legalization showed the biggest improvements, suggesting regulation may have positive effects for high-risk users.

Why did frequent users improve the most?

Possible explanations include access to regulated products with known potency, reduced involvement in illegal markets, and normalization reducing stigma-related barriers to help-seeking.

Read More on RethinkTHC

Cite This Study

RTHC-07099·https://rethinkthc.com/research/RTHC-07099

APA

McDonald, André J; Doggett, Amanda; Belisario, Kyla; Gillard, Jessica; De Jesus, Jane; Vandehei, Emily; Lee, Laura; Halladay, Jillian; MacKillop, James. (2025). Cannabis Use and Misuse Following Recreational Cannabis Legalization.. JAMA network open, 8(4), e256551. https://doi.org/10.1001/jamanetworkopen.2025.6551

MLA

McDonald, André J, et al. "Cannabis Use and Misuse Following Recreational Cannabis Legalization.." JAMA network open, 2025. https://doi.org/10.1001/jamanetworkopen.2025.6551

RethinkTHC

RethinkTHC Research Database. "Cannabis Use and Misuse Following Recreational Cannabis Lega..." RTHC-07099. Retrieved from https://rethinkthc.com/research/mcdonald-2025-cannabis-use-and-misuse

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.