Omega-3 Supplementation During Pregnancy Reverses THC-Induced Heart Deficits in Rat Offspring

Maternal THC exposure led to decreased birthweight and early cardiac deficits in offspring. Dietary omega-3 supplementation reversed both THC-induced fetal growth restriction and postnatal cardiac deficits. The protective effect appeared to involve alterations in cardiac and hepatic fatty acids, reduced cardiac collagen deposition, and decreased cardiac endocannabinoid system signaling.

Rat model with maternal THC exposure and dietary omega-3 (DHA and EPA) supplementation. Assessed fetal growth, postnatal cardiac outcomes, cardiac and hepatic fatty acid profiles, collagen deposition, and endocannabinoid system markers.

This is the first study to explore an intervention for maternal THC-induced cardiovascular deficits in offspring. With rising cannabis use in pregnancy and emerging evidence of cardiac consequences, a dietary intervention like omega-3s could be clinically practical.

If omega-3 supplementation can mitigate THC-induced fetal harm, it could be recommended as a harm reduction strategy for pregnant women who continue cannabis use. However, this would need human confirmation and should not be interpreted as making cannabis use safe in pregnancy.

Animal model. Single THC dose regimen may not reflect human use patterns. Omega-3 dose may not be achievable through diet alone. Long-term offspring outcomes not assessed. Cannot determine if omega-3 fully prevents or merely reduces harm.