Heart Rate Variability Drops Immediately After Cannabis Smoking in Young Adults with CUD

African American young adults with cannabis use disorder showed significant decreases in heart rate variability and increases in heart rate immediately after smoking cannabis, indicating reduced parasympathetic activity.

RTHC-06809Observational StudyLow2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Observational Study
Evidence
Low
Sample
N=31

What This Study Found

In 31 young adults with CUD wearing Garmin smartwatches for 3 days, both time-domain and frequency-domain HRV metrics were significantly lower after cannabis smoking compared to before, with a corresponding increase in average heart rate.

Key Numbers

31 participants; 84% women; mean age 19.7 years; significant decreases in both time and frequency domain HRV after smoking; significant increase in heart rate.

How They Did This

Observational study of 31 African American undergraduates (84% women, mean age 19.7) meeting criteria for CUD via the MINI interview. Participants wore Garmin smartwatches for 3 consecutive days and reported cannabis smoking sessions via survey. HRV was measured via photoplethysmography.

Why This Research Matters

Cannabis is often perceived as relaxing, but this study shows it acutely reduces parasympathetic nervous system activity in habitual users. For people with cannabis use disorder, repeated suppression of heart rate variability could have cardiovascular implications over time.

The Bigger Picture

Low heart rate variability is associated with increased cardiovascular risk, poorer stress adaptation, and worse health outcomes. If cannabis chronically suppresses parasympathetic function in heavy users, this adds to a growing body of evidence about cardiovascular effects of regular cannabis use.

What This Study Doesn't Tell Us

Small sample (n = 31) predominantly female. Consumer-grade smartwatch HRV measurement is less precise than clinical ECG. Self-reported smoking times may be inaccurate. No control for concurrent tobacco or other substance use.

Questions This Raises

  • ?Does chronic cannabis use lead to persistent reductions in baseline HRV?
  • ?Are these acute cardiovascular effects different across consumption methods (smoking vs. edibles vs. vaping)?

Trust & Context

Key Stat:
HRV significantly decreased after each cannabis smoking session
Evidence Grade:
Small observational study using consumer-grade wearable devices without a control group.
Study Age:
2025 publication
Original Title:
Parasympathetic decreases immediately following self-reported cannabis smoking among adults living with cannabis use disorder.
Published In:
International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 214, 113211 (2025)
Database ID:
RTHC-06809

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
What do these levels mean? →

Frequently Asked Questions

Does cannabis affect heart rate variability?

In this study of young adults with cannabis use disorder, HRV (a measure of parasympathetic nervous system activity) dropped significantly immediately after smoking cannabis, while heart rate increased. Lower HRV is generally associated with poorer cardiovascular health.

Is smoking cannabis bad for your heart?

This study found cannabis smoking acutely reduces parasympathetic nervous system function (measured by HRV) in habitual users. While the long-term cardiovascular implications are not yet clear, repeatedly suppressing HRV could be a concern over time.

Read More on RethinkTHC

Cite This Study

RTHC-06809·https://rethinkthc.com/research/RTHC-06809

APA

Keen, Larry; Kuno, Caroline Bena; Morris, Alexis. (2025). Parasympathetic decreases immediately following self-reported cannabis smoking among adults living with cannabis use disorder.. International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 214, 113211. https://doi.org/10.1016/j.ijpsycho.2025.113211

MLA

Keen, Larry, et al. "Parasympathetic decreases immediately following self-reported cannabis smoking among adults living with cannabis use disorder.." International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2025. https://doi.org/10.1016/j.ijpsycho.2025.113211

RethinkTHC

RethinkTHC Research Database. "Parasympathetic decreases immediately following self-reporte..." RTHC-06809. Retrieved from https://rethinkthc.com/research/keen-2025-parasympathetic-decreases-immediately-following

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.