Daily Cannabis Use Linked to 40% Higher Heart Disease Risk in Adults Under 50

Each 90-day increase in annual cannabis use was associated with 9% higher odds of heart disease (aOR 1.09, 95% CI: 1.03-1.15). Daily users had 40% higher odds (aOR 1.40, 95% CI: 1.11-1.76). A clear positive linear dose-response relationship was observed after controlling for demographics, smoking, and heavy drinking.

Cross-sectional analysis of 88,166 U.S. adults aged 18-49 from the 2021-2023 National Survey on Drug Use and Health. Cannabis use frequency measured as past-year use days. Weighted logistic regression and dose-response analysis controlling for demographics, smoking, and heavy drinking.

Heart disease in younger adults is rising, and cannabis use is increasing in the same population. This dose-response relationship — more cannabis use equals more heart disease risk — identifies cannabis as a potential modifiable risk factor for early-onset cardiovascular disease.

Combined with the heart failure study (RTHC-08238), a consistent picture is emerging: cannabis use is associated with meaningful cardiovascular risk, particularly with frequent use. For young adults who view cannabis as harmless, this dose-response data provides important context.

Cross-sectional — cannot prove cannabis causes heart disease. Self-reported cannabis use and heart disease diagnosis. Residual confounding despite controlling for smoking and drinking. Cannot distinguish smoking from other consumption methods.