Adolescent vaping of THC, CBD, and synthetic cannabinoids all increased from 2021 to 2023

Among nearly 70,000 US middle and high schoolers, vaping of all cannabinoid types increased from 2021 to 2023, with 2.55 million teens vaping THC and synthetic cannabinoid use doubling among 11-13 year olds.

Chung, Jack et al.·American journal of preventive medicine·2025·Strong EvidenceCross-Sectional
RTHC-06227Cross SectionalStrong Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Cross-Sectional
Evidence
Strong Evidence
Sample
N=69,899

What This Study Found

Significant increases in vaping of THC, CBD, and synthetic cannabinoids from 2021-2023; THC vaping peaked in 2022 while synthetic continued rising; prevalence higher among females than males in 2023; use doubled among 11-13 year olds.

Key Numbers

69,899 students; 2023: 7.4% (2.55M) vaping THC, 2.9% (999K) vaping CBD, 1.8% (620K) vaping synthetic cannabinoids; females exceeded males in 2023; 11-13 year old THC and synthetic use doubled 2021-2023.

How They Did This

Three waves of National Youth Tobacco Survey (2021-2023); 69,899 US middle and high school students aged 11-18; weighted prevalence estimates by year, age, and sex.

Why This Research Matters

The rise in synthetic cannabinoid vaping among the youngest adolescents is alarming given unknown health effects, while overall cannabis vaping continues spreading across all cannabinoid types.

The Bigger Picture

The rapid growth of synthetic cannabinoid vaping among adolescents represents an emerging public health crisis with unknown long-term consequences.

What This Study Doesn't Tell Us

Self-reported data; students may not know what cannabinoid they are vaping; "don't know" responses for synthetics tripled (awareness issue); school-based survey misses dropouts.

Questions This Raises

  • ?Why are females now vaping cannabinoids more than males?
  • ?What are the health effects of synthetic cannabinoid vaping in adolescents?
  • ?Are students aware they may be consuming synthetic cannabinoids?

Trust & Context

Key Stat:
2.55 million US adolescents were vaping THC in 2023, with synthetic cannabinoid use doubling among 11-13 year olds
Evidence Grade:
Large nationally representative youth survey with three annual waves, though self-reported data and potential misidentification of substances are limitations.
Study Age:
Published 2025, data from 2021-2023
Original Title:
Adolescent Cannabis Vaping Trends (2021-2023): Delta-9-Tetrahydrocannabinol, Cannabidiol, and Synthetic Cannabinoids.
Published In:
American journal of preventive medicine, 69(6), 107655 (2025)
Database ID:
RTHC-06227

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

A snapshot of a population at one point in time.

What do these levels mean? →

Frequently Asked Questions

How many teens are vaping cannabis?

An estimated 2.55 million US adolescents (7.4%) were vaping THC in 2023, with nearly 1 million vaping CBD and 620,000 vaping synthetic cannabinoids.

Which age group saw the biggest increase?

The youngest group (ages 11-13) saw THC and synthetic cannabinoid vaping prevalence double between 2021 and 2023.

Read More on RethinkTHC

Cite This Study

RTHC-06227·https://rethinkthc.com/research/RTHC-06227

APA

Chung, Jack; Lim, Carmen C W; Stjepanović, Daniel; Hall, Wayne; Connor, Jason P; Chan, Gary C K. (2025). Adolescent Cannabis Vaping Trends (2021-2023): Delta-9-Tetrahydrocannabinol, Cannabidiol, and Synthetic Cannabinoids.. American journal of preventive medicine, 69(6), 107655. https://doi.org/10.1016/j.amepre.2025.107655

MLA

Chung, Jack, et al. "Adolescent Cannabis Vaping Trends (2021-2023): Delta-9-Tetrahydrocannabinol, Cannabidiol, and Synthetic Cannabinoids.." American journal of preventive medicine, 2025. https://doi.org/10.1016/j.amepre.2025.107655

RethinkTHC

RethinkTHC Research Database. "Adolescent Cannabis Vaping Trends (2021-2023): Delta-9-Tetra..." RTHC-06227. Retrieved from https://rethinkthc.com/research/chung-2025-adolescent-cannabis-vaping-trends

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.