What Pharmacists Need to Know About Medical Marijuana's Effects on Developing Brains

A review for pharmacists summarizes the evidence on cannabis's therapeutic uses alongside its impact on the developing brain, emphasizing the pharmacist's role in counseling patients and families about risks and benefits of medical marijuana in young patients.

RTHC-07887ReviewModerate Evidence2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Review
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

The review covers cannabis's established therapeutic applications (chronic pain, epilepsy, chemotherapy-induced nausea, MS spasticity, IBD) while highlighting evidence that cannabis exposure during brain development can affect cognition, memory, and executive function, underscoring the need for pharmacist education and patient counseling.

Key Numbers

Therapeutic areas reviewed: chronic pain, multiple sclerosis, epilepsy, chemotherapy-induced nausea/vomiting, inflammatory bowel disease. Focus age range: developing minds (children and adolescents).

How They Did This

Narrative review published in the Journal of Pediatric Pharmacology and Therapeutics, synthesizing the history of medical marijuana, current pharmacological evidence, and neurodevelopmental impact literature, with a focus on the pharmacist's clinical role.

Why This Research Matters

As more states legalize medical marijuana and pediatric indications expand (especially CBD for epilepsy), pharmacists are on the front line of patient education. This review equips them with evidence-based talking points about both benefits and developmental risks.

The Bigger Picture

Pharmacists are often the most accessible healthcare professionals and play a crucial role in cannabis education. As the gap between legal access and clinical knowledge widens, reviews like this help ensure healthcare providers can offer balanced, evidence-based guidance.

What This Study Doesn't Tell Us

Narrative review — not systematic. Broad scope may sacrifice depth on individual topics. Pharmacist-focused perspective may not address physician or patient needs. Rapid changes in the field may outpace published reviews.

Questions This Raises

  • ?Are pharmacy curricula keeping pace with expanding cannabis indications?
  • ?How do pharmacists balance respecting patient autonomy with warning about developmental risks?
  • ?Should pharmacists play a more active role in monitoring pediatric cannabis prescriptions?

Trust & Context

Key Stat:
Evidence Grade:
Narrative review in a specialized pharmacy journal, providing a useful clinical synthesis but not a systematic evaluation of the evidence.
Study Age:
Published 2025.
Original Title:
Under the Influence: Cognitive Effects of Medical Marijuana on Developing Minds.
Published In:
The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 30(4), 440-449 (2025)
Database ID:
RTHC-07887

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

Summarizes existing research on a topic.

What do these levels mean? →

Frequently Asked Questions

Is medical marijuana safe for children?

CBD (Epidiolex) is FDA-approved for certain childhood epilepsies and has a strong safety profile. However, THC-containing products carry developmental concerns for young brains. The benefit-risk balance depends on the specific condition and should involve the care team.

What should pharmacists know about cannabis?

Pharmacists need to understand therapeutic indications, dosing, drug interactions (especially with CYP450 enzymes), developmental risks for young patients, and how to counsel patients who may be using cannabis alongside other medications.

Read More on RethinkTHC

Cite This Study

RTHC-07887·https://rethinkthc.com/research/RTHC-07887

APA

Vuong, Marry; Parkhill, Kaylee. (2025). Under the Influence: Cognitive Effects of Medical Marijuana on Developing Minds.. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 30(4), 440-449. https://doi.org/10.5863/JPPT-25-01209

MLA

Vuong, Marry, et al. "Under the Influence: Cognitive Effects of Medical Marijuana on Developing Minds.." The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2025. https://doi.org/10.5863/JPPT-25-01209

RethinkTHC

RethinkTHC Research Database. "Under the Influence: Cognitive Effects of Medical Marijuana ..." RTHC-07887. Retrieved from https://rethinkthc.com/research/vuong-2025-under-the-influence-cognitive

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.