Synthetic Cannabinoid Mojo Caused a Heart Attack in a Healthy 32-Year-Old
A 32-year-old with no cardiac risk factors had a heart attack with complete artery blockage four hours after smoking Mojo.
Quick Facts
What This Study Found
A 32-year-old with ASCVD risk 3.6% presented with chest pain 4 hours after smoking Mojo. Total occlusion of left circumflex artery. Treated with PCI and stent.
Key Numbers
Age 32; ASCVD risk 3.6%; symptoms 4 hours post-use; total artery occlusion; successful PCI.
How They Did This
Case report with ECG, emergent catheterization, and urine toxicology.
Why This Research Matters
Synthetic cannabinoids are full agonists, far more potent than natural cannabis, and can cause life-threatening cardiac events in healthy young adults.
The Bigger Picture
Full agonism at cannabinoid receptors triggers sympathetic activation, platelet aggregation, and endothelial injury.
What This Study Doesn't Tell Us
Single case. Cannot prove causation. Mojo composition varies.
Questions This Raises
- ?How common are synthetic cannabinoid cardiac events?
- ?Should EDs test for synthetic cannabinoids in young MI patients?
Trust & Context
- Key Stat:
- Evidence Grade:
- Well-documented case but single report.
- Study Age:
- 2025 case report of synthetic cannabinoid-induced STEMI.
- Original Title:
- Synthetic Cannabinoid (Mojo)-Induced ST-Segment Elevation Myocardial Infarction: A Case Report.
- Published In:
- Cureus, 17(5), e84570 (2025)
- Authors:
- Udoh, Kubiat E, Udoh, Kuseme E, Udoh, Andikan E
- Database ID:
- RTHC-07835
Evidence Hierarchy
Frequently Asked Questions
Can synthetic cannabinoids cause heart attacks?
Yes. This documents a heart attack in a healthy 32-year-old after smoking Mojo.
Are synthetic cannabinoids more dangerous than marijuana?
Yes — they are full agonists making them more potent and unpredictable.
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Cite This Study
https://rethinkthc.com/research/RTHC-07835APA
Udoh, Kubiat E; Udoh, Kuseme E; Udoh, Andikan E. (2025). Synthetic Cannabinoid (Mojo)-Induced ST-Segment Elevation Myocardial Infarction: A Case Report.. Cureus, 17(5), e84570. https://doi.org/10.7759/cureus.84570
MLA
Udoh, Kubiat E, et al. "Synthetic Cannabinoid (Mojo)-Induced ST-Segment Elevation Myocardial Infarction: A Case Report.." Cureus, 2025. https://doi.org/10.7759/cureus.84570
RethinkTHC
RethinkTHC Research Database. "Synthetic Cannabinoid (Mojo)-Induced ST-Segment Elevation My..." RTHC-07835. Retrieved from https://rethinkthc.com/research/udoh-2025-synthetic-cannabinoid-mojoinduced-stsegment
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.