What cardiovascular risks are associated with cannabis use?

A review of emerging evidence suggests cannabis use may pose serious cardiovascular risks, including associations with ischemic stroke and up to a fivefold increase in myocardial infarction risk, particularly in younger men.

O'Keefe, Evan L et al.·Current opinion in psychology·2021·Moderate EvidenceReview
RTHC-03389ReviewModerate Evidence2021RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Review
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

Cannabis consumption was associated with increased ischemic stroke risk and an almost fivefold increase in myocardial infarction, primarily in the period immediately following consumption. Males in their 30s appeared to bear the greatest burden. Edible preparations were linked to more cardiovascular-related emergency department visits than combustible forms.

Key Numbers

Almost 5-fold increase in myocardial infarction risk; males in their 30s most affected; cannabis smoke contains PAHs, aromatic amines, and nitric oxide, some at higher concentrations than tobacco

How They Did This

Narrative review synthesizing existing evidence on cardiovascular effects of cannabis, including data on combustible and edible forms, chemical components (aromatic amines, PAHs), and vascular complications.

Why This Research Matters

Cannabis is now the most popular inhaled substance in the US, surpassing tobacco. The cardiovascular risks may be placing a younger, traditionally low-risk population in danger of major cardiac events.

The Bigger Picture

The cardiovascular risk profile of cannabis complicates its perception as a safer alternative to tobacco. The finding that edibles may cause more cardiac ER visits than smoking challenges assumptions about the relative safety of different consumption methods.

What This Study Doesn't Tell Us

Narrative review without systematic methodology. Much of the evidence is observational and cannot establish causation. Research is described as "nascent" by the authors themselves.

Questions This Raises

  • ?Does the cardiovascular risk differ between occasional and chronic users?
  • ?Are CBD-dominant products associated with the same cardiac risks as THC-dominant ones?
  • ?Why do edibles appear to cause more cardiac ER visits?

Trust & Context

Key Stat:
~5x myocardial infarction risk increase
Evidence Grade:
Narrative review synthesizing observational evidence. Specific risk estimates should be interpreted cautiously pending larger prospective studies.
Study Age:
Published in 2021; cardiovascular research on cannabis has been expanding rapidly.
Original Title:
Reevaluating America's Latest Pharmaceutical Trend: The Cardiovascular Risk of Cannabis.
Published In:
Current opinion in psychology, 38, 31-37 (2021)
Database ID:
RTHC-03389

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

Summarizes existing research on a topic.

What do these levels mean? →

Frequently Asked Questions

Can cannabis cause a heart attack?

Observational evidence links cannabis use to an almost fivefold increase in myocardial infarction risk, particularly in the moments immediately following consumption. However, this is based on observational data and cannot confirm causation.

Are edibles safer for the heart than smoking?

Not necessarily. This review notes that edible preparations have been linked to more cardiovascular-related emergency department visits than combustible forms, though the reasons are not fully understood.

Who is most at risk?

Based on current evidence, males in their 30s appear to bear the greatest burden of cannabis-related cardiovascular events, a group traditionally considered low risk for heart problems.

Read More on RethinkTHC

Cite This Study

RTHC-03389·https://rethinkthc.com/research/RTHC-03389

APA

O'Keefe, Evan L; Peterson, Tyler M; Lavie, Carl J. (2021). Reevaluating America's Latest Pharmaceutical Trend: The Cardiovascular Risk of Cannabis.. Current opinion in psychology, 38, 31-37. https://doi.org/10.1016/j.copsyc.2020.07.002

MLA

O'Keefe, Evan L, et al. "Reevaluating America's Latest Pharmaceutical Trend: The Cardiovascular Risk of Cannabis.." Current opinion in psychology, 2021. https://doi.org/10.1016/j.copsyc.2020.07.002

RethinkTHC

RethinkTHC Research Database. "Reevaluating America's Latest Pharmaceutical Trend: The Card..." RTHC-03389. Retrieved from https://rethinkthc.com/research/o-keefe-2021-reevaluating-americas-latest-pharmaceutical

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.