Cannabis-related intractable vomiting hospitalizations increased significantly from 2010 to 2014

Hospitalizations for intractable vomiting with cannabis use disorder rose significantly over five years, with 41% of patients also having tobacco dependence and rising rates of anxiety.

Madireddy, Sowmya et al.·Cureus·2019·Moderate EvidenceRetrospective Cohort
RTHC-02153Retrospective CohortModerate Evidence2019RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Retrospective Cohort
Evidence
Moderate Evidence
Sample
N=9,601

What This Study Found

Hospitalizations for intractable vomiting with CUD showed a significant increasing trend from 2010-2014 (N=9,601 total). Anxiety disorders increased from 20.8% to 30.8% as a comorbidity, while depression decreased from 19.2% to 16.4%. Concomitant tobacco abuse/dependence was present in 41.2% of patients.

Key Numbers

9,601 hospitalizations total (2010-2014); significant increasing trend; anxiety comorbidity rose from 20.8% to 30.8%; depression fell from 19.2% to 16.4%; tobacco co-use 41.2%.

How They Did This

Retrospective cohort study using the Nationwide Inpatient Sample (2010-2014), identifying patients aged 16-50 with primary diagnosis of intractable vomiting and cannabis use disorder.

Why This Research Matters

As cannabis use increases, so do its paradoxical gastrointestinal side effects. The rising hospitalization trend predated widespread legalization, suggesting the problem may have worsened further since this data was collected.

The Bigger Picture

CHS hospitalizations represent a growing and underappreciated cost of cannabis use. The association with increasing anxiety comorbidity suggests that mental health factors may influence who develops this syndrome.

What This Study Doesn't Tell Us

Administrative database study relying on discharge codes. CHS may be underdiagnosed and coded inconsistently. Cannot determine cannabis potency, frequency, or product type from billing data.

Questions This Raises

  • ?Has the trend accelerated post-legalization?
  • ?Does higher-potency cannabis correlate with higher CHS rates?
  • ?Why is anxiety increasing while depression is decreasing as a comorbidity?

Trust & Context

Key Stat:
9,601 hospitalizations in 5 years
Evidence Grade:
Moderate: large national database but reliant on administrative coding.
Study Age:
Published in 2019.
Original Title:
Burden of Comorbidities in Hospitalizations for Cannabis Use-associated Intractable Vomiting during Post-legalization Period.
Published In:
Cureus, 11(8), e5502 (2019)
Database ID:
RTHC-02153

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-ControlFollows or compares groups over time
This study
Cross-Sectional / Observational
Case Report / Animal Study

Looks back at existing records to find patterns.

What do these levels mean? →

Frequently Asked Questions

Are CHS hospitalizations increasing?

Yes, this study found a significant upward trend in cannabis-related intractable vomiting hospitalizations from 2010-2014 in a national US database.

What other conditions do CHS patients have?

Common comorbidities included anxiety disorders (rising to 30.8%), depression, and tobacco dependence (41.2%).

Read More on RethinkTHC

Cite This Study

RTHC-02153·https://rethinkthc.com/research/RTHC-02153

APA

Madireddy, Sowmya; Patel, Rikinkumar S; Ravat, Virendrasinh; Ajibawo, Temitope; Lal, Anthony; Patel, Jenil; Patel, Riddhi; Goyal, Hemant. (2019). Burden of Comorbidities in Hospitalizations for Cannabis Use-associated Intractable Vomiting during Post-legalization Period.. Cureus, 11(8), e5502. https://doi.org/10.7759/cureus.5502

MLA

Madireddy, Sowmya, et al. "Burden of Comorbidities in Hospitalizations for Cannabis Use-associated Intractable Vomiting during Post-legalization Period.." Cureus, 2019. https://doi.org/10.7759/cureus.5502

RethinkTHC

RethinkTHC Research Database. "Burden of Comorbidities in Hospitalizations for Cannabis Use..." RTHC-02153. Retrieved from https://rethinkthc.com/research/madireddy-2019-burden-of-comorbidities-in

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.