Global Meta-Analysis: 29% of Medical Students Have Tried Cannabis at Least Once

A meta-analysis of 109 studies across 32 countries found 29.2% lifetime cannabis prevalence among medical students, with rates declining from the 1970s through the 2000s before rebounding in the 2020s.

Karpovisch, Eduardo et al.·Revista brasileira de psiquiatria (Sao Paulo·2025·ModerateSystematic Review and Meta-Analysis
RTHC-06797Systematic Review and Meta AnalysisModerate2025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Systematic Review and Meta-Analysis
Evidence
Moderate
Sample
N=62,444

What This Study Found

Across 62,444 medical students from 32 countries, lifetime cannabis prevalence was 29.2%, past-year 20.5%, past-month 9.2%, and past-week 5.1%. Prevalence declined from 38.4% in the 1970s to 18.1% in the 2000s, then rebounded to 30.4% in the 2020s, driven by increases in Latin America, Asia, and Africa.

Key Numbers

109 studies; 62,444 participants; 32 countries; lifetime prevalence 29.2%; Anglo-Saxon America highest at 59.7%; Asia lowest at 11.5%; 2020s rebound to 30.4%.

How They Did This

Systematic review and meta-analysis of 109 observational studies published 1971-2025, identified from six databases. Data pooled using random-effects models with subgroup analyses by gender, study cycle, school type, decade, and world region.

Why This Research Matters

Medical students represent a population that will eventually counsel patients about cannabis. Understanding their own use patterns and how those have shifted over five decades provides context for how the medical profession interfaces with cannabis culture.

The Bigger Picture

The rebound in medical student cannabis use during the 2020s, particularly in regions where legalization or decriminalization is expanding, parallels broader population trends. The wide regional variation (11.5% in Asia vs. 59.7% in Anglo-Saxon America) highlights how cultural and legal contexts shape use patterns.

What This Study Doesn't Tell Us

Heterogeneity across 109 studies spanning five decades and 32 countries. Self-reported use subject to underreporting, especially in regions with strict prohibition. Different survey instruments and definitions of use across studies.

Questions This Raises

  • ?Does personal cannabis experience among medical students influence their clinical attitudes toward medical cannabis?
  • ?What is driving the 2020s rebound in medical student cannabis use in Latin America, Asia, and Africa?

Trust & Context

Key Stat:
29.2% lifetime prevalence across 62,444 medical students globally
Evidence Grade:
Large meta-analysis spanning decades and continents, though limited by heterogeneity in underlying studies and self-report bias.
Study Age:
2025 publication covering studies from 1971-2025
Original Title:
Global temporal and regional trends in cannabis use among medical students: A systematic review and meta-analysis.
Published In:
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) (2025)
Database ID:
RTHC-06797

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
What do these levels mean? →

Frequently Asked Questions

How common is cannabis use among medical students?

Globally, about 29% of medical students have tried cannabis at least once, 20.5% used in the past year, and 9.2% in the past month, based on a meta-analysis of 109 studies across 32 countries.

Is cannabis use increasing among medical students?

After declining from 38.4% in the 1970s to 18.1% in the 2000s, lifetime prevalence rebounded to 30.4% in the 2020s, with increases driven by Latin America, Asia, and Africa.

Read More on RethinkTHC

Cite This Study

RTHC-06797·https://rethinkthc.com/research/RTHC-06797

APA

Karpovisch, Eduardo; Alves, Gabriel Grando; Folgierini, Vicente Fichbein; Braun, Luiza Elizabete; Porto, Ighor Miron; Hoffmann, Mauricio Scopel; Pacheco, João Pedro Gonçalves. (2025). Global temporal and regional trends in cannabis use among medical students: A systematic review and meta-analysis.. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). https://doi.org/10.47626/1516-4446-2025-4286

MLA

Karpovisch, Eduardo, et al. "Global temporal and regional trends in cannabis use among medical students: A systematic review and meta-analysis.." Revista brasileira de psiquiatria (Sao Paulo, 2025. https://doi.org/10.47626/1516-4446-2025-4286

RethinkTHC

RethinkTHC Research Database. "Global temporal and regional trends in cannabis use among me..." RTHC-06797. Retrieved from https://rethinkthc.com/research/karpovisch-2025-global-temporal-and-regional

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkTHC research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.